New gene linked to schizophrenia discovered by team of Indian, Australian scientists

After 18 years of research, Indian and Australian scientists have identified a new gene directly linked to schizophrenia. Using DNA from thousands of people in India, the team has found clues in the quest for the causes of schizophrenia, and for potential treatments. Scientists from the University of Queensland in Australia and a team of Indian researchers searched the genomes of over 3,000 individuals and found those with schizophrenia were more likely to have a particular genetic variation.The team of Indian researchers was led by R Thara, co-founder and director of the Chennai-based Schizophrenia Research Foundation.Bryan Mowry from the University of Queensland said such studies had predominantly been done in populations with European ancestry, with more than 100 schizophrenia-associated variants identified previously.[caption id="attachment_6942731" align="alignnone" width="1280"]

Representational image.[/caption]"Looking at other populations can highlight different parts of the genome with a more robust association with the disease," Dr Mowry said. "This study identified a gene called NAPRT1 that encodes an enzyme involved in vitamin B3 metabolism — we were also able to find this gene in a large genomic dataset of schizophrenia patients with European ancestry," he said."When we knocked out the NAPRT1 gene in zebrafish, brain development of the fish was impaired — we are now working to understand more deeply how this gene functions in the brain," Dr Mowry said. "Our studies aim to shed more light on what makes people susceptible to schizophrenia and possible treatments for the future," Dr Mowry added.According to a statement released by the university, Dr Mowry and Dr Thara met in the late 1990s when they discussed studying a population in India."Thara is a driving force for research into schizophrenia in India and her team in Chennai has been central in recruiting patients, while QBI has been able to fund the processing of blood samples they’ve collected," Dr Mowry said.